Key Takeaways
- Liv's prescribing protocol starts NAD+ injections at 100 mg twice weekly for the first month, then steps to 200 mg twice weekly from month two.
- If the step-up doesn't suit you, your provider can hold you at the month-one schedule, or keep the same strength and space doses to once weekly.
- Nasal spray and oral drops each run on their own schedule, so use the row for your format.
- NAD+ helps your cells turn food into energy and supports enzymes that maintain DNA.
Before you start, it helps to picture your first few months: how much, how often and when it changes. The chart below shows the schedule Liv's providers work from, and your provider sets yours.
Liv's NAD+ Injection Dosage Chart
| Route | Month 1 | Month 2 onward | If side effects appear |
|---|---|---|---|
| Injection | 100 mg twice weekly | 200 mg twice weekly | Drop to once weekly at the same strength, or hold at the month-1 schedule |
| Nasal spray | One spray per nostril, one to two times daily | Same | Reduce frequency on your prescriber's instruction |
| Oral liposomal | 50 mg daily | 100 mg daily in month 2, 150 mg daily in month 3 | Hold at the current step |
The nasal schedule totals 60 to 120 mg a day depending on whether you use it once or twice.
Source: Liv's prescribing protocol, version 1 dated 10.2024, revised 04.2026.
How to Read It
The Columns Are a Schedule, Not a Target
The protocol steps up at month two, and it also lets your provider hold you at 100 mg twice weekly, or keep the same strength and space doses to once weekly. Either way, your provider sets your schedule around how you're doing.
Each Route Runs on Its Own Schedule
Each route has its own schedule, so a daily nasal dose can't be converted into an injection dose.
HOW THE SCHEDULE MOVES
Not a straight line up.
- Month 1 100 mg twice weekly
- Review with your prescriber
- Month 2 200 mg twice weekly
- Ongoing reviewed each quarter
At the review: hold at month 1, or drop to once weekly at the same strength.
Your provider sets your own schedule.
Where the Schedule Comes From
It comes from Liv's prescribing protocol, a written schedule that clinicians created and update as they learn. Your provider reviews your history and fits it to you.
A state-licensed compounding pharmacy prepares your NAD+ specifically for you, based on your prescription.
What NAD+ Does in Your Cells
NAD+ helps your cells turn the food you eat into usable energy. It moves the energy in carbohydrates, fats and proteins into ATP, the molecule your cells use to power their work.
More than 400 enzymes need it, and no other helper molecule made from a vitamin works with as many. Other enzymes use it to maintain your DNA and help control which genes are switched on.
You'll find food sources, supplements and more in the NAD guide.
Side Effects and Safety Notes
Your provider stays involved from your first dose:
- If side effects show up: on the twice-weekly schedule, Liv's protocol lets your provider keep the same strength and prescribe it less often, or hold you at month one.
- If you already take nicotinamide riboside: say so at your evaluation, because a standalone NAD+ prescription alongside it may not be appropriate.
- Regular check-ins: a short questionnaire before each refill, and a check-in every three months.
Tell your provider about side effects before changing your dose, and contact them about anything new or anything that doesn't settle.
When the Chart Does Not Apply
In any of these cases, check with your provider instead of the chart.
- You're on a different route. Compare the nasal spray and the injection by how each fits your week, not by converting the numbers.
- Your prescription reads differently. Follow it. Your provider wrote it for you, based on your history.
- You want to change your schedule. Holding, stepping up or spacing out doses is a decision your provider makes with you.
Getting the Number That Applies to You
At an evaluation, you tell a licensed provider about yourself and your health history. They decide whether treatment is right for you and prescribe only if it is. An initial consult covers a three-month supply, dispensed as one month with two refills if prescribed. After that, a check-in every three months keeps your plan going.
Each check-in is a chance to adjust your schedule with your provider, so it keeps fitting you.