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$50 off your 12-week supply with code ESTRADIOL50

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Estradiol CreamRx

$187.00
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    • No membership or hidden fees
    • 24/7 care team support throughout the journey
    • Compounded in the USA in FDA regulated pharmacies
Comfort matters. So does intimacy. Prescription vaginal estradiol cream may ease moderate to severe vaginal symptoms after menopause, including dryness and pain during sex.

  • Free same day shipping

  • HIPAA secure

  • HSA/FSA Eligible

  • No insurance required

What’s Included

All plans include:

  • A telehealth visit with a licensed provider
  • Estradiol vaginal cream, as prescribed
  • Provider review before every refill, at no extra cost
  • Instructions for use with your prescription
  • Free shipping
  • Usual delivery: 3 to 5 days after approval
  • Your care team, whenever you need them
How can vaginal estradiol cream help me feel more comfortable?

Estradiol cream may help ease moderate to severe vaginal symptoms after menopause, such as dryness, irritation and pain during sex. The goal is more comfort in your day and more ease with intimacy.

How does LIV Health ensure quality and safety?

A provider licensed in your state reviews your health history and lab results before prescribing and reviews your care before each refill. Any compounded medicine comes from a licensed pharmacy. Your care team is available between refills.

What’s included in my plan?

No membership fee. Your plan includes medicine, shipping and ongoing support, with provider review before every refill at no extra cost. You're billed on the schedule you choose and can skip a shipment or cancel anytime from your account.

womens/lifestyle/tile
womens/lifestyle/tile

Make Intimacy More Comfortable

Less irritation

May help ease vaginal irritation during everyday activities.

More comfortable intimacy

May help reduce vaginal pain during sex.

Relief from dryness

May help relieve vaginal dryness after menopause.

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Your Care Team Is Here to Help

  • A provider reviews labs and history before approval
  • Delivered to your door after approval
  • Change your plan, skip or cancel from your account
Get Started
womens/estradiol/tile/cream
womens/estradiol/tile/cream
womens/estradiol/tile/cream

Less Dryness, More Comfortable Sex

Less discomfort can make a difference in your day and during intimacy.

8 weeks

Women said sex was less painful after eight weeks of using vaginal estradiol.*

85.5%ofwomen

85.5% of women after menopause had relief from vaginal symptoms while using vaginal estradiol.**

Sources and study details

* For 8 weeks: Original source. Kroll et al., Menopause (2018), primary paper PMC5779318, Results and Figure 2A. Sexually active postmenopausal women with moderate to severe pain during sex as most bothersome symptom. Modified ITT estradiol n=239 and vehicle n=233. Studied 0.003% estradiol cream, 15 micrograms/application, daily for 2 weeks then three times weekly for 10 weeks. At week 8 mean severity change on 0 to 3 scale was -1.5 with estradiol and -1.2 with vehicle (P=0.004); improvement also at week 12. Group improvement, not guaranteed onset or complete resolution for every woman. Study instructions are not prescribing advice. This study followed women using vaginal estradiol cream after menopause.

** For 85.5%: Simunic et al., 2003, 12-month randomized trial of 1,612 women, with 828 assigned vaginal estradiol. Success combined patient-reported and clinically assessed vaginal-atrophy symptoms; the placebo rate was 41.4%. Tablets were used daily for two weeks and twice weekly thereafter. This was 25 mcg; your prescribed product and strength may differ. Original study. The 85.5% figure is an overall treatment-response assessment combining patient-reported symptoms and clinical signs of vaginal atrophy (tissue thinning); it does not mean all women became symptom-free or that each symptom improved by 85.5%.

How it Works

Three Steps to Get Started

Today

Start online, then complete your required labs.

After approval

Delivery usually takes 3 to 5 days.

Ongoing Support

Your provider adjusts your plan as you go.

Help Center

Find answers to common questions about treatments, results, prescriptions and what to expect. Still have questions?
How does LIV work?

Start with an online health form. Labs are required for this treatment. A licensed provider reviews your information and decides whether to prescribe. If prescribed, your medicine is delivered to you. You'll complete a short questionnaire before each refill and check in every three months.

Do I need an in-person appointment?

Your intake starts online, without booking an appointment. Labs are required for this treatment. A licensed provider reviews your history and results before prescribing.

How long does it take to get my prescription?

A licensed provider reviews your intake within 48 hours and must also review your lab results before prescribing. Once your prescription is approved, delivery usually takes 3 to 5 days. In-stock prescriptions approved before 1 PM Eastern ship that day. Compounding can add time.

How will I know if the cream is helping?

Pay attention to the symptoms that brought you here: dryness, irritation or pain during sex. Share any changes with your provider, along with side effects or concerns. They can review your response and adjust the plan if needed.

Who decides whether this is right for me?

A licensed provider reviews your health history and lab results. They decide whether treatment is right for you, choose your dose and how much to prescribe, and review your plan before refills.

What does compounded mean?

Compounded means a licensed pharmacy mixes the medicine for one person. It is not made in large batches. The FDA does not approve compounded medicines for safety, quality or how they are made.

Can I change, skip or cancel my plan?

Yes. You can change your plan, skip a shipment or cancel from your account. If you want to change your treatment or dose, discuss it with your provider.

What symptoms is vaginal estradiol cream used for?

Vaginal estradiol cream may ease moderate to severe vaginal dryness, irritation and pain during sex after menopause. The approved cream label calls these symptoms vulvar and vaginal atrophy. Your provider explains the directions for your own prescription.

Can a vaginal cream affect the rest of my body?

Yes. Some estrogen from vaginal cream can be absorbed into your body. That is why the warnings, precautions and side effects for estrogen taken by mouth also matter, even with a vaginal cream.

What risks should I talk through with my provider?

The approved Mylan 0.01% estradiol cream label carries an FDA boxed warning. In women who have a uterus, using estrogen alone raises the risk of cancer of the uterine lining (endometrial cancer). Adding a progestin reduces the risk of endometrial hyperplasia, a thickening of that lining that can come before cancer.

The warning also describes stroke and blood clots in a leg (deep vein thrombosis) with estrogen alone or combined with a progestin. For the combination, it also includes clots in the lungs (pulmonary embolism), heart attack (myocardial infarction) and invasive breast cancer.

Both types of treatment carry a warning about probable dementia, based on studies of women age 65 and older. Talk through these risks with your provider so you understand what they mean for the medicine prescribed for you.